Single Cell RNA-seq Sheds Light on the Role of Microglia in Alzheimer’s Disease
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In this webinar, Dr. Swarup, demonstrates the protective functions of microglia in reducing CAA, blood-brain barrier dysfunction, and brain calcification. Examination of human AD tissue and iPSC-microglia demonstrates that microglia phagocytose calcium crystals and is impaired by the loss of the AD risk gene, TREM2.
The absence of microglia in Alzheimer’s disease mice shifts pathologies from parenchymal amyloid plaques to cerebral amyloid angiopathy, brain calcification and hemorrhages, and early death. However, injection of adult microglia prevents each of these pathological changes.
