Overview
Many autoimmune diseases are characterized by aberrant B cells which play a central role in pathogenesis. Each B cell expresses a B cell receptor (BCR), which determines its specificity in binding to different epitopes. For autoimmune diseases such as Type 1 Diabetes, Multiple Sclerosis, Rheumatoid Arthritis, Crohn's, and Celiac; our current understanding of the role of unique BCR repertoires is poorly understood. However, recent advances in single-cell RNA sequencing has allowed the field to simultaneously profile both the BCR and whole transcriptome leading to the characterization of clonal diversity of B cell subtypes.
