The Parse Biosciences Evercode workflow offers a novel solution for scRNA-seq, incorporating efficient multiplexed split-pool combinatorial RNA barcoding, which enables up to a million cells to be prepared and sequenced in a single experiment. Here, we present an approach utilizing INTEGRA ASSIST PLUS liquid handler, a low cost semi-automated multichannel platform, to automate the Evercode combinatorial barcoding steps, streamlining the workflow, and reducing the manual bench time by 75%.