Watch our on-demand webinar where Nina A. Barr, M.Sc., PhD Candidate in Dr. Derrick J. Morton's lab at the University of Southern California, will share her work using CRISPR-engineered human cerebellar organoids and single cell RNA sequencing to study how RNA exosome dysfunction contributes to neurodevelopmental disease.
Her work reveals that disease-associated EXOSC3 variants impair the timing and coordination of developmental gene expression programs, leading to stalled cell state transitions, altered cerebellar organization, and reduced neuronal network synchrony, with especially pronounced effects in Purkinje cells and rhombic lip-derived populations.
What you’ll learn by watching:
-How human cerebellar organoids can model EXOSC3-associated neurodevelopmental disease
-How single cell RNA sequencing reveals disrupted developmental timing and lineage progression
-How RNA exosome dysfunction affects cerebellar organization and neuronal network coordination
-How RNA surveillance may help explain selective vulnerability in the developing nervous system
.png)
