Chronic stress is associated with increased anxiety, cognitive deficits, and post-traumatic stress disorder. Repeated social defeat (RSD) in mice induces many similar responses, including accelerated fear acquisition, delayed fear extinction, and increased fear memory. The mechanisms underlying stress-sensitization are unclear, but enhanced fear memory may be critical.
In this webinar, Ethan Goodman explained how single-cell sequencing was used to identify the key cells and critical signaling pathways in the brain responsible for a heightened fear response due to social stress in mice, providing insights into the molecular mechanisms underlying stress-related behavioral changes.
