On-Demand Webinar

Distressed: Identifying the mechanisms behind stress induced fear and anxiety

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Chronic stress is associated with increased anxiety, cognitive deficits, and post-traumatic stress disorder. Repeated social defeat (RSD) in mice induces many similar responses, including accelerated fear acquisition, delayed fear extinction, and increased fear memory. The mechanisms underlying stress-sensitization are unclear, but enhanced fear memory may be critical. 

In this webinar, Ethan Goodman explained how single-cell sequencing was used to identify the key cells and critical signaling pathways in the brain responsible for a heightened fear response due to social stress in mice, providing insights into the molecular mechanisms underlying stress-related behavioral changes.

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Ethan Goodman

Ohio State University

PhD Student